ProteinCartography↗ identifies proteins similar to your input protein using sequence and structure searches. It then compares each structure to every other structure and creates interactive maps like the ones here.
The interactive map created by the pipeline is a UMAP, which is a lower dimensional representation of the high dimensional all-v-all comparison. This is meant primarily for visualization.
Additionally, the pipeline groups similar structures together using Leiden clustering. Proteins in the same Leiden cluster are likely to be similar. These clusters can be seen in the “Leiden cluster” option in the color dropdown.